Roflumilast

Overview
Catalog #	bs-82545c-10-mg
Product Name	Roflumilast
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective phosphodiesterase (PDE4) inhibitor, IC50=0.7, 0.9, 0.7, 0.2 nM for PDE4A1, PDE4A4, PDE4B1 and PDE4B2 respectively1. Clinically useful agent for treatment of COPD2. Improves sensory gating in humans3 and improves memory in rodent models4. Mimics calorie restriction effects via activation of AMPK/SIRT1 and protects against diabetic nephropathy5. Reduces weight gain by increasing energy expenditure and improves glucose metabolism in mice6.
Description	CAS Number: 162401-32-3 Chemical Name: 3(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-benzamide Molecular weight: 403.21 Formula: C17H14N2Cl2F2O3 Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC, NMR (Conforms)