SC-560

Overview
Catalog #	bs-82516c-5-mg
Product Name	SC-560
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	SC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.2
Description	CAS Number: 188817-13-2 Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole Molecular weight: 352.74 Formula: C17H12ClF3N2O Solubility: DMSO (>25 mg/ml) Ethanol (10 mg/ml) Physical Properties: Brown solid Purity: >98%, NMR (Conforms)