Stattic

Overview
Catalog #	bs-82513c-10-mg
Product Name	Stattic
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	STAT3 inhibitor. Inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation1. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT32. Exhibits potent antitumor activity3. Protects against angiotensin II-induced vascular dysfunction and hypertension4. An extremely useful tool to probe involvement of STAT3 in cellular signaling.
Description	CAS Number: 19983-44-9 Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide Molecular weight: 211.20 Formula: C8H5NO4S Solubility: DMSO (10 mg/ml) Ethanol (1 mg/ml) Physical Properties: Light yellow solid Purity: 98% by TLC, NMr (Conforms)