Leflunomide
Overview | |
Catalog # | bs-82474c-50-mg |
Product Name | Leflunomide |
Specifications | |
Storage Buffer | Tan solid (MP = 168-170°C) |
Storage Condition | RT |
Target | |
Product Information | A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury3. |
Description | CAS Number: 75706-12-6 Chemical Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide Molecular weight: 270.21 Formula: C12H9F3N2O2 Solubility: DMSO (30 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (conforms) |