L-Cycloserine

Overview
Catalog #	bs-82450c-20-mg
Product Name	L-Cycloserine
Specifications
Storage Buffer	Light yellow solid
Storage Condition	-20°C
Target
Product Information	L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4
Description	CAS Number: 339-72-0 Chemical Name: (S)-4-Amino-3-isoxaolidinone Molecular weight: 102.09 Formula: C3H6N2O2 Solubility: DMSO (20 mg/ml) with warming, Water (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)