VX-702

Overview
Catalog #	bs-82426c-10-mg
Product Name	VX-702
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	A potent and selective inhibitor of p38 MAP kinases, p38 MAPK and p38 (KD = 3.7 and 17 nM respectively).1 Inhibits IL-6, IL-1 and TNF production in LPS-primed blood.1 Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 M.2 Provides only modest clinical efficacy in rheumatoid arthritis.3,4 Delays platelet lesions and leads to better maintenance of stored platelets.5
Description	CAS Number: 745833-23-2 Chemical Name: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide Molecular weight: 404.32 Formula: C19H12F4N4O2 Solubility: DMSO (40 mg/ml) Ethanol (2 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)