Sorafenib (base)

Overview
Catalog #	bs-82422c-10-mg
Product Name	Sorafenib (base)
Specifications
Storage Buffer	Off-white solid (possibly lyophilized, check lot)
Storage Condition	-20°C
Target
Product Information	Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM)1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation of MAPK pathway and ERK phosphorylation3. Induces caspase-independent apoptosis in melanoma cells4. Clinically useful anticancer agent.
Description	CAS Number: 475207-59-1 Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide Molecular weight: 464.83 Formula: C21H16ClF3N4O3 Solubility: DMSO (200 mg/ml) Ethanol (3 mg/ml) Physical Properties: Off-white solid Purity: 99% by TLC, NMR (Conforms)