Pemetrexed

Overview
Catalog #	bs-82420c-10-mg
Product Name	Pemetrexed
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5
Description	CAS Number: 357166-29-1 Chemical Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt Molecular weight: 597.49 Formula: C20H19N5O6 • 2Na • 7H2O Solubility: Water (100 mg/ml) Physical Properties: White solid Purity: 98% by TLC and HPLC, NMR (Conforms)