GW-2580
| Overview | |
| Catalog # | bs-82410c-5-mg |
| Product Name | GW-2580 |
| Specifications | |
| Storage Buffer | solid |
| Storage Condition | RT |
| Target | |
| Product Information | Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM)1. Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo. |
| Description | CAS Number: 870483-87-7 Chemical Name: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine Molecular weight: 366.32 Formula: C20H22N4O3 Solubility: DMSO (40 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC, NMR (Conforms) |
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