Erlotinib · HCl

Overview
Catalog #	bs-82407c-10-mg
Product Name	Erlotinib · HCl
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM)1. Potent inhibitor of mutant JAK2-V617F2. Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) ErbB-4 kinase (Ki = 1.5 μM)3. HDAC inhibitors sensitize for erlotinib activity in EGFR-mutated and wildtype non-small cell lung cancer (NSCLC) cells4. A clinically effective agent for NSCLC5.
Description	CAS Number: 183319-69-9 Chemical Name: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride Molecular weight: 429.91 Formula: C22H23N3O4 · HCl Solubility: DMSO (18 mg/ml) Physical Properties: White or off-white solid Purity: 98% by TLC, NMR (Conforms)