Bosutinib

Overview
Catalog #	bs-82400c-5-mg
Product Name	Bosutinib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5
Description	CAS Number: 380843-75-4 Chemical Name: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile Molecular weight: 530.45 Formula: C26H29Cl2N5O3 Solubility: DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming) Physical Properties: Off-white solid Purity: >98% by HPLC, NMR (Conforms)