Gliotoxin

Overview
Catalog #	bs-82378c-1-mg
Product Name	Gliotoxin
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	A fungal metabolite with immunosuppressive properties; blocks phagocytosis, cytokine production and proliferation of T and B cells.1 Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. It inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells.5
Description	CAS Number: 67-99-2 Chemical Name: (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino [1,2-a]indole-1,4-dione; Molecular weight: 326.39 Formula: C13H14N2O4S2 Solubility: DMSO (15 mg/ml) Physical Properties: White lyophilized solid Purity: 98% by HPLC NMR (Conforms)