Candesartan

Overview
Catalog #	bs-82367c-50-mg
Product Name	Candesartan
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1 Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2α or endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis.2 Attenuates angiogenesis in hepatocellular carcinoma.3 Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease.4 Active in vivo and orally active.
Description	CAS Number: 139481-59-7 Chemical Name: 2-Ethoxy-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid Molecular weight: 400.45 Formula: C24H20N6O3 Solubility: DMSO (40 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)