Manidipine dihydrochloride

Overview
Catalog #	bs-82365c-20-mg
Product Name	Manidipine dihydrochloride
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Manidipine is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature. Manidipine has recently been found to be an inhibitor (IC50 = 4.8 µM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 µM) via inhibition of the Immediate-Early 2 (IE2) protein.4
Description	CAS Number: 89226-75-5 Chemical Name: 5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride Molecular weight: 683.63 Formula: C35H38N4O6·2HCl Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (conforms)