NAcM-OPT

Overview
Catalog #	bs-82353c-5-mg
Product Name	NAcM-OPT
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1 It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1
Description	CAS Number: 2089293-61-6 Chemical Name: 1-Benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea Molecular weight: 434.40 Formula: C23H29Cl2N3O Solubility: DMSO (30 mg/ml) Ethanol (20 mg/ml) Physical Properties: White solid Purity: 98% by HPLC/TLC NMR (Conforms)