JIB-04

Overview
Catalog #	bs-82350c-5-mg
Product Name	JIB-04
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model.1 Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2 Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3
Description	CAS Number: 199596-05-9 Chemical Name: (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine Molecular weight: 308.76 Formula: C17H13ClN4 Solubility: DMSO (30 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)