UNC-2170 HCl
| Overview | |
| Catalog # | bs-82319c-5-mg |
| Product Name | UNC-2170 HCl |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1 |
| Description | CAS Number: 1648707-58-7 Chemical Name: 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride Molecular weight: 349.69 Formula: C14H21BrN2O HCl Solubility: DMSO (40 mg/ml) Water (50 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms) |
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