BTB-1

Overview
Catalog #	bs-82314c-10-mg
Product Name	BTB-1
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	A selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 M.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5
Description	CAS Number: 86030-08-2 Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)-benzene Molecular weight: 297.71 Formula: C12H8ClNO4S Solubility: DMSO (30 mg/ml) Physical Properties: White or off-white solid Purity: 98% by HPLC NMR (Conforms)