L524-0366
| Overview | |
| Catalog # | bs-82311c-5-mg |
| Product Name | L524-0366 |
| Specifications | |
| Storage Buffer | Orange solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 µM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. It completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM1. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics2. |
| Description | CAS Number: 951612-19-4 Chemical Name: (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone Molecular weight: 308.79 Formula: C13H13ClN4OS Solubility: DMSO (14 mg/ml) Ethanol (2 mg/ml) Physical Properties: Beige solid Purity: 98% by TLC, NMR (Conforms) |
Powered by Bioz