PD-150606

Overview
Catalog #	bs-82296c-5-mg
Product Name	PD-150606
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	A selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices1. Displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death2. Some protective effects may be due to inhibition of MMP activity3.
Description	CAS Number: 179528-45-1 Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid Molecular weight: 306.12 Formula: C9H7IO2S Solubility: DMSO (30 mg/ml) Ethanol (15 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)