FLI-06

Overview
Catalog #	bs-82287c-5-mg
Product Name	FLI-06
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	FLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 M).1 Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma.2 Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells.3
Description	CAS Number: 313967-18-9 Chemical Name: Molecular weight: 438.52 Formula: C25H30N2O5 Solubility: DMSO (50 mg/ml) Ethanol (10 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (conforms)