LY-364947
Overview | |
Catalog # | bs-82281c-5-mg |
Product Name | LY-364947 |
Specifications | |
Storage Buffer | White or slightly yellow solid |
Storage Condition | RT |
Target | |
Product Information | Selective ALK5 inhibitor, IC50 = 59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively1. Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion2. Abolishes resistance of glioblastoma-initiating cells to radiation3. Cell permeable. |
Description | CAS Number: 396129-53-6 Chemical Name: 4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone Molecular weight: 272.31 Formula: C17H12N4 Solubility: DMSO (25 mg/ml) Physical Properties: Beige solid Purity: 98% by TLC |