PRT4165

Overview
Catalog #	bs-82270c-10-mg
Product Name	PRT4165
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2
Description	CAS Number: 31083-55-3 Chemical Name: 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione Molecular weight: 235.24 Formula: C15H9NO2 Solubility: DMSO (25 mg/ml) Ethanol (6 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)