AI-1
| Overview | |
| Catalog # | bs-82266c-5-mg |
| Product Name | AI-1 |
| Specifications | |
| Storage Buffer | Tan solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | A novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology1. Cell permeable. |
| Description | CAS Number: 75483-04-4 Chemical Name: 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester Molecular weight: 265.70 Formula: C13H12ClNO3 Solubility: DMSO (15 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms) |
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