GSK-1702934A
| Overview | |
| Catalog # | bs-82247c-5-mg |
| Product Name | GSK-1702934A |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | RT |
| Target | |
| Product Information | TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 μM and 0.44 μM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1μM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1μM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2 |
| Description | CAS Number: 924377-85-5 Chemical Name: 1-(1-(5,6,7,8-Tetrahydro=4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl)-1H-benzo[d]- imidazole-2(3H)-one Molecular weight: 396.53 Formula: C22H26N3O2S Solubility: DMSO (50 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC (5% CH3OH in CH2Cl2 Rf=0.34) |
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