680C91

Overview
Catalog #	bs-82245c-5-mg
Product Name	680C91
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM)1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4.
Description	CAS Number: 163239-22-3 Chemical Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole Molecular weight: 238.27 Formula: C15H11FN2 Solubility: DMSO (20 mg/ml) Ethanol (10 mg/ml) Physical Properties: Light brown solid Purity: 98% by TLC, NMR (Conforms)