CZC-54252

Overview
Catalog #	bs-82233c-5-mg
Product Name	CZC-54252
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	Novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. Attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM)1. The G2019S mutant is a common mutation found in familial Parkinson’s disease patients2. Cell permeable.
Description	CAS Number: 1191911-27-9 Chemical Name: N-[[[5-Chloro-2-[[2-methoxy-4-(4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-phenyl]methanesulfonamide hydrochloride Molecular weight: 541.46 Formula: C22H25ClN6O4S · HCl Solubility: DMSO (50 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC, NMR (Conforms)