LM22A-4

Overview
Catalog #	bs-82224c-5-mg
Product Name	LM22A-4
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, it caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats1. Improves respiratory function in a mouse models of Rett syndrome2.
Description	CAS Number: 37988-18-4 Chemical Name: N,N’N’ Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide Molecular weight: 339.35 Formula: C15H21N3O6 Solubility: DMSO (50 mg/ml) Water (50 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)