GSK-J1

Overview
Catalog #	bs-82218c-5-mg
Product Name	GSK-J1
Specifications
Storage Buffer	Tan solid
Storage Condition	RT
Target
Product Information	Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
Description	CAS Number: 1373422-53-7 Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine Molecular weight: 389.46 Formula: C22H23N5O2 Solubility: DMSO (20 mg/ml) Physical Properties: Pale yellow solid Purity: 99% by TLC, NMR (Conforms)