Spautin-1

Overview
Catalog #	bs-82205c-5-mg
Product Name	Spautin-1
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes1. Deranges dengue virion maturation2. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells3. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency4. Cell permeable.
Description	CAS Number: 1262888-28-7 Chemical Name: 6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine Molecular weight: 271.27 Formula: C15H11F2N3 Solubility: DMSO (50 mg/ml) Ethanol (15 mg/ml with warming) Physical Properties: Tan solid Purity: 98% by TLC, NMR (Conforms)