NSC663284

Overview
Catalog #	bs-82193c-5-mg
Product Name	NSC663284
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B1. Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation2. Inhibits the growth of a variety of human tumor cell lines3. Acts via irreversible oxidation of the catalytic cysteine of CDC254.
Description	CAS Number: 383907-43-5 Chemical Name: 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione Molecular weight: 321.77 Formula: C15H16ClN3O3 Solubility: DMSO (15 mg/ml) Ethanol (55 mg/ml) Physical Properties: Red solid Purity: 98% by TLC, NMR (Conforms)