6-Thioguanine
| Overview | |
| Catalog # | bs-82152c-100-mg |
| Product Name | 6-Thioguanine |
| Specifications | |
| Storage Buffer | Tan solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity. |
| Description | CAS Number: 154-42-7 Chemical Name: 2-Amino-6-mercaptopurine Molecular weight: 167.19 Formula: C5H5N5S Solubility: DMF (1.5 mg/ml) Physical Properties: Pale yellow solid Purity: 96% by HPLC NMr (Conforms) |
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