5-Fluorouracil
| Overview | |
| Catalog # | bs-82149c-250-mg |
| Product Name | 5-Fluorouracil |
| Specifications | |
| Storage Buffer | White or off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | 5-Fluorouracil (5-FU) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-FU are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-FU is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1 |
| Description | CAS Number: 51-21-8 Chemical Name: 5-Fluoro-1H,3H-pyrimidine-2,4-dione Molecular weight: 130.08 Formula: C4H3FN2O2 Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: 98% |
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