Cytarabine

Overview
Catalog #	bs-82148c-500-mg
Product Name	Cytarabine
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells.1,2 It Cellular enzymes convert it to its nucleotide form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it.3,4 For the same reasons, it is also employed as an antiviral.5 It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).6,7
Description	CAS Number: 147-94-4 Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone Molecular weight: 243.22 Formula: C9H13N3O5 Solubility: DMSO (12 mg/ml) Water (24 mg/ml) Physical Properties: White or off-white solid Purity: 98% by HPLC NMR (Conforms)