GSK-1016790A

Overview
Catalog #	bs-82129c-5-mg
Product Name	GSK-1016790A
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	A novel and potent TRPV4 channel agonist. GSK1016790A induced Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300-fold more potent than 4α-PDD and is a valuable tool for investigating the role of TRPV4 in physiological processes.
Description	CAS Number: 942206-85-1 Chemical Name: (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide Molecular weight: 655.62 Formula: C28H32Cl2N4O6S2 Solubility: DMSO (10 mg/ml) Physical Properties: white solid Purity: 98% by TLC, NMR (Conforms)