Sulindac Sulfone

Overview
Catalog #	bs-82080c-5-mg
Product Name	Sulindac Sulfone
Specifications
Storage Buffer	Yellow solid
Storage Condition	RT
Target
Product Information	Metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases.1 Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells.2
Description	CAS Number: 59864-04-9 Chemical Name: (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid Molecular weight: 372.41 Formula: C20H17FO4S Solubility: DMSO (25 mg/ml) Physical Properties: Yellow solid Purity: >98% by TLC [10% methanol / methylene chloride, Rf = 0.40] NMR (Conforms)