AG-490

Overview
Catalog #	bs-82062c-5-mg
Product Name	AG-490
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.
Description	CAS Number: 133550-30-8 Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N¬-(phenylmethyl)-2-propenamide Molecular weight: 294.31 Formula: C17H14N2O3 Solubility: DMSO (25 mg/ml) DMF (40 mg/ml) Ethanol (10 mg/ml) Physical Properties: Tan solid Purity: 98% by TLC [ 10% methanol in methylene chloride, Rf = 0.50] NMR Conforms