MK-886

Overview
Catalog #	bs-82026c-5-mg
Product Name	MK-886
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. Also inhibits PPARα (80% inhibition at 10 µM).3
Description	CAS Number: 118414-82-7 Chemical Name: 3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid Molecular weight: 472.08 Formula: C27H34ClNO2S Solubility: DMSO (40 mg/ml) Physical Properties: White solid Purity: 98% by TLC [ 5% methanol in methylene chloride; Rf = 0.35] NMR conforms