Arecoline HBr

Overview
Catalog #	bs-82005c-250-mg
Product Name	Arecoline HBr
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3
Description	CAS Number: 300-08-3 Chemical Name: 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide Molecular weight: 236.11 Formula: C8H13NO2 HBr Solubility: Water (50 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)