Veliparib 2HCl (ABT-888)
| Overview | |
| Catalog # | bs-80508C |
| Product Name | Veliparib 2HCl (ABT-888) |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:317.2 Formula:C13H16N4O • 2HCl Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Water (up to 40 mg/ml). Chemical Name:2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride |
| Description | PanPARP inhibitor (Ki = 5.2 PARP1 and 2.9 nM PARP2)1. Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells4. |
Powered by Bioz