Leflunomide

Overview
Catalog #	bs-80494C
Product Name	Leflunomide
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:270.21 Formula:C12H9F3N2O2 Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml). Chemical Name:5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Description	A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury3.