Pirfenidone
| Overview | |
| Catalog # | bs-80480C |
| Product Name | Pirfenidone |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:185.23 Formula:C12H11NO Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) Chemical Name:5-Methyl-1-phenyl-2(1H)-pyridinone |
| Description | Antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2 (Regulator of G-protein Signaling 2) which represents a new mechanism of pirfenidone action.3 Inhibits fibroblast proliferation.4 Suppresses TNFα production at the translational level.5 Scavenges hydroxyl radicals and inhibits lipid peroxidation in a dose-dependent manner.6 Recently approved therapeutic agent for idiopathic pulmonary fibrosis.7 Orally active. |
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