L-Cycloserine

Overview
Catalog #	bs-80467C
Product Name	L-Cycloserine
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:102.1 Formula:C3H6N2O2 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml, warm) or in Water (up to 25 mg/ml). Chemical Name:(S)-4-Amino-3-isoxazolidinone
Description	Down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase)1. The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme1. It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence4.