Picropodophyllotoxin

Overview
Catalog #	bs-80446C
Product Name	Picropodophyllotoxin
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:414.42 Formula:C22 H22 O8 Purity:>98% Solubility:Soluble in DMSO (up to 40 mg/ml). Chemical Name:(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro¬-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7¬]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Description	Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP1. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM1. Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 M2. Exhibits antiangiogenic activitiy3. Attenuates intimal hyperplasia after vascular injury4. Active in vivo.