Vatalanib 2HCl

Overview
Catalog #	bs-80443C
Product Name	Vatalanib 2HCl
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:419.73 Formula:C20H15ClN4 2HCl Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml) Chemical Name:N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Description	Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM)1. Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 µM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 µM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.