Vismodegib

Overview
Catalog #	bs-80442C
Product Name	Vismodegib
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:421.30 Formula:C19H14Cl2N2O3S Purity:>98% Solubility:Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 10 mg/ml with warming) Chemical Name:2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide
Description	A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2 Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, IC50s=1.4 and 3.0 μM respectively.3 Clinically useful for the treatment of basal cell carcinoma.4 Inhibits proliferation and induces apoptosis in colon cancer cell lines.