VX-702

Overview
Catalog #	bs-80441C
Product Name	VX-702
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:404.32 Formula:C19H12F4N4O2 Purity:>98% Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml) Chemical Name:6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
Description	A potent and selective inhibitor of p38 MAP kinases, p38 MAPK and p38 (KD = 3.7 and 17 nM respectively).1 Inhibits IL-6, IL-1 and TNF production in LPS-primed blood.1 Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 M.2 Provides only modest clinical efficacy in rheumatoid arthritis.3,4 Delays platelet lesions and leads to better maintenance of stored platelets.5