Pemetrexed 2Na

Overview
Catalog #	bs-80436C
Product Name	Pemetrexed 2Na
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:597.5 Formula:C20H19N5Na2O6 [7H2O] Purity:>98% Solubility:Soluble in Water (up to 100 mg/ml). Chemical Name:N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt
Description	Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 µM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 µM)1. A clinically useful anticancer agent2. Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas3. Activation of AMPK is associated with pemetrexed resistance4. Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells5.