H89 · 2HCl

Overview
Catalog #	bs-80428C
Product Name	H89 · 2HCl
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:519.28 Formula:C20H20BrN3O2S·2HCl Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) or in Water (up to 10 mg/ml). Chemical Name:N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
Description	H-89 is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM). Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).1,2