Dovitinib

Overview
Catalog #	bs-80420C
Product Name	Dovitinib
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:392.4 Formula:C21H21FN6O Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml). Chemical Name:4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
Description	Potent receptor tyrosine kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM)1. Selectively blocks growth B9 cells transformed by wild type or activated mutant FGFR32. Induces autophagy and apoptosis in human breast cancer cells by regulating SHP-1-dependent STAT3 inhibition3. Also enhances BMP-2-induced osteoblast differentiation in mouse myoblast cells4. Clinically useful cancer treatment5.